Key Takeaways

  • At Avantier, innovation in optical design continues to unlock new frontiers in imaging performance.
  • Recent developments in high-throughput and large field-of-view microscope objectives demonstrate how precision optics are accelerating breakthroughs in gene sequencing, biomedical diagnostics, and semiconductor inspection.
  • Here’s a look at four cutting-edge microscope objectives developed to meet the demanding needs of these rapidly evolving industries.

High-Throughput Microscope Objective for Gene Sequencing Instruments

A significant leap forward in life sciences, Avantier has developed a high-throughput microscope objective specifically designed for next-generation gene sequencing systems. Engineered for visible light imaging, the objective delivers a wide 2 mm field of view with a numerical aperture (NA) of 1.0, achieving diffraction-limited image quality across the field.

This advanced objective has already been adopted by a global leader in gene sequencing technology. Its integration has contributed directly to achieving the world’s highest daily throughput for gene sequencing, supporting fast, accurate, and scalable genomic analysis for both research and clinical applications.

Large Field-of-View, High-Resolution Microscope Objective

To address the growing need for wide-area, high-detail imaging in diagnostics and life sciences, Avantier developed a microscope objective that balances centimeter-level coverage with micron-level resolution.

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objectives for gene sequencing, Advanced Microscope Objectives, objectives for biomedicine, semiconductor inspection

Large Field-of-View, High-Resolution Microscope Objective

Key specifications include:

  • Field of view: 10 mm
  • Resolution: as fine as 1.0 µm
  • Working distance: >25 mm
  • Spectral range: Visible to near-infrared

This objective is ideally suited for precision diagnostic systems, enabling clear, high-resolution imaging of large biological samples. Beyond healthcare, its design supports emerging applications in biomedicine, life sciences research, and machine vision—where both resolution and coverage are critical.

High-Throughput Ultraviolet Microscope Objective, objectives for gene sequencing, Advanced Microscope Objectives, objectives for biomedicine, semiconductor inspection
High-Throughput Ultraviolet Microscope Objective

Developed in collaboration with a publicly listed semiconductor equipment manufacturer, the objective features:

  • Numerical aperture (NA): 0.9
  • Field of view: >1 mm
  • Spectral range: 355–500 nm
  • Wavefront aberration: <0.025λ
  • MTF: >0.25 at 3000 lp/mm
  • Physical resolution: better than 200 nm

Avantier also offers custom UV and deep-UV objectives (down to 260 nm), designed for high-throughput inspection tasks. These solutions help chipmakers meet the increasing demands of next-generation semiconductor devices.

Microscope Optical System for Lithography Alignment Mark Detection

Precision alignment is a cornerstone of modern lithography. To support accurate pattern placement, Avantier has engineered a microscope optical system specifically for detecting alignment marks on wafers. The system includes:
  • High- and low-magnification tube lenses
  • Optimized microscope objectives
  • A finely tuned illumination system
The system achieves a physical resolution of 1.5 μm with exceptional imaging performance across both visible and ultraviolet wavelengths. By capturing crisp images of alignment marks, this solution plays a crucial role in enabling 10 nm-level positioning accuracy—a key requirement for advanced node semiconductor fabrication.
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Low- and High-Magnification Focusing Microscope Optical System
Resolution Imaging Test Results, objectives for gene sequencing, Advanced Microscope Objectives, objectives for biomedicine, semiconductor inspection
Resolution Imaging Test Results

Meeting the Future of Imaging Head-On

Whether accelerating genome sequencing, improving diagnostic precision, or enabling next-generation chip manufacturing, Avantier’s advanced microscope objectives and imaging systems are engineered to meet the highest standards of performance. With deep expertise in optical design and customization, Avantier continues to support its partners across biotechnology, healthcare, and high-tech industries.

For more information on our microscope objective capabilities or to request a custom design, contact us.

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